Section 2: Relationship
Between Gene Expression and Traits
We
know that an organism's traits are controlled by genes. But how exactly do
genes exert control over traits? The discussion above prompts us to consider
that genes and traits do not always have a one-to-one correspondence. What does
this mean? Relationship Between Gene Expression Products and
Traits Over
a century ago, Mendel studied the contrasting traits of round and wrinkled
peas, offering a brilliant explanation through his theory of genetic factors.
Today, how can we provide a deeper explanation from the perspective of gene
expression? It turns out that the DNA of wrinkled peas contains an inserted
foreign DNA sequence, disrupting the gene encoding starch branching enzyme.
This disruption leads to an abnormality in starch branching enzyme activity,
significantly reducing starch content within cells. Starch plays a role in
retaining water within cells. When peas mature, those with high starch content
effectively retain moisture, appearing plump, whereas those with low starch
content shrink due to dehydration (Figure 4-9). From
the above example, it's evident that genes control metabolic processes by
regulating enzyme synthesis, thereby influencing an organism's traits. For
instance, albinism in humans results from an abnormal gene encoding tyrosinase.
Tyrosinase, present in normal human skin and hair, converts tyrosine into
melanin. If a person lacks tyrosinase due to a genetic anomaly, melanin cannot
be synthesized, resulting in symptoms of albinism. Furthermore,
genes can directly control traits by influencing protein structure. For
example, in approximately 70% of cystic fibrosis patients, there is a deletion
of three nucleotides in the gene encoding CFTR protein, a transporter protein.
This deletion causes a phenylalanine deficiency at position 508 of the CFTR
protein, altering its spatial structure. As a consequence, CFTR's ability to
transport chloride ions is compromised, leading to excessive mucus production
in the bronchi, obstructing airways, and promoting bacterial growth in the
lungs, ultimately severely impairing lung function. Selective Gene Expression and Cellular Differentiation The
formation of various traits in an organism is based on cellular
differentiation. Different types of cells within the same organism have
identical genes, yet they exhibit different morphologies, structures, and
functions. Why is this so? Scientists
have found that genes in cells are selectively expressed; in different types of
cells, expressed genes can be broadly categorized into two types. One type
includes genes expressed in all cells, guiding the synthesis of proteins
essential for maintaining basic cellular activities, such as ribosomal protein genes
and ATP synthase genes. The other type includes genes specifically expressed in
certain types of cells, such as ovalbumin genes and insulin genes. The essence
of cellular differentiation lies in selective gene expression, which is
regulated by gene expression control mechanisms. Epigenetics When
and where genes are expressed, as well as the level of their expression, are
all regulated, directly influencing traits. In
the examples above, even though the nucleotide sequences of the Lcyc gene in
the morning glory and the A" gene in mice remain unchanged, some
nucleotides undergo methylation modifications (Figure 4-10), suppressing gene
expression and thereby affecting phenotype. This DNA methylation modification
can be inherited, causing offspring to exhibit the same phenotype. This
phenomenon, where genetic sequences remain unchanged but heritable changes
occur in gene expression and phenotype, is called epigenetic inheritance. Epigenetic
phenomena are widespread throughout the entire life cycle of organisms,
influencing growth, development, and aging processes. For example, slight
differences between genetically identical monozygotic twins are related to
epigenetic inheritance. In a bee colony, both the queen bee and worker bees
develop from fertilized eggs, but they differ significantly in morphology,
structure, physiology, and behavior due to epigenetic inheritance playing a
crucial role. Interested students can refer to additional literature to learn
more about examples of epigenetic inheritance. In
summary, genes control traits through their expression products—proteins.
Whether genes are expressed in cells and the level of their expression are
tightly regulated. The essence of cellular differentiation results from
selective gene expression. Epigenetic inheritance allows organisms to exhibit
heritable changes in traits without changes in the genetic sequence. In
most cases, the relationship between genes and traits is not straightforward.
Multiple genes can influence a single trait, such as human height, where each
gene has a certain effect on height. Conversely, a single gene can influence
multiple traits. For instance, researchers in China discovered that the Ghd7
gene in rice not only regulates flowering but also plays a crucial role in the
growth, development, and yield of rice. Additionally, traits are not solely
determined by genes; environmental factors also play a significant role. For
example, nutrition and physical exercise postnatally significantly affect human
height, and the formation of two types of leaves in "problem
exploration" is also related to environmental factors. Genes
interact with other genes, gene expression products, and the environment in a
complex network, finely regulating the traits of organisms. |
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