Section
1: Gene Mutations and Gene Recombination Organisms
undergoing sexual reproduction replicate chromosomes during the formation of
gametes, essentially duplicating genetic material DNA. The principle of
complementary base pairing ensures the accuracy of DNA replication, maintaining
consistent genetic information between parent and offspring. However, can
errors occur during the replication of genetic information? Examples
of Gene Mutations Sickle cell anemia (also known as sickle cell disease) is a
genetic disorder. In normal individuals, red blood cells are centrally indented
discs, whereas in sickle cell anemia patients, red blood cells are
crescent-shaped (Figure 5-1, right). These abnormal red blood cells are prone
to rupture, causing hemolytic anemia and, in severe cases, death. What is the
cause of this disease? Analysis of the hemoglobin molecules in patients' red
blood cells revealed amino acid substitutions in the peptide chains of
hemoglobin molecules (Figure 5-2). Substitutions
of bases can lead to changes in genes, thereby altering the encoded proteins.
So, if there is an addition or deletion of bases in the gene sequence encoding
a protein, will it also lead to changes in protein structure and thus changes
in traits? The answer is yes. Changes in DNA molecules due to base
substitutions, additions, or deletions that alter the gene base sequence are
called gene mutations. If
gene mutations occur in gametes, they will follow the laws of inheritance and
be passed on to offspring. If they occur in somatic cells, they generally
cannot be inherited. However, some plants with mutations in somatic cells can
pass them on through asexual reproduction. Cell
Transformation Cancer is one of the most serious threats to human health. Is
cell transformation related to gene mutations? Let's take colorectal cancer as
an example. DNA
in human and animal cells already contains genes related to carcinogenesis:
oncogenes and tumor suppressor genes. Generally, proteins expressed by
oncogenes are necessary for normal cell growth and proliferation. If these
genes mutate or are overexpressed, leading to excessive protein activity, they
can cause cell transformation. Conversely, proteins expressed by tumor
suppressor genes can inhibit cell growth and proliferation or promote
apoptosis. Mutation of these genes, leading to reduced or lost protein
activity, can also cause cell transformation. Compared to normal cells, cancer
cells (Figure 5-3) exhibit the following characteristics: unlimited
proliferation, significant changes in morphology, reduced substances like
glycoproteins on the cell membrane, significantly reduced intercellular
adhesion, and easy dispersal and metastasis within the body. Causes
of Gene Mutations How are gene mutations generated? In 1927, American
geneticist H.J. Muller (1890-1967) discovered that irradiating fruit flies with
X-rays significantly increased the number of mutant offspring. In the same
year, scientists irradiated seeds of maize and barley with X-rays and gamma
rays, obtaining similar results. Since then, it has been gradually discovered
that factors that can induce gene mutations and increase mutation frequency can
be categorized into three types: physical factors, chemical factors, and
biological factors. For example, ultraviolet light, X-rays, and other radiation
can damage DNA inside cells; nitrites, base analogs, and other substances can
alter nucleic acid bases; and the genetic material of certain viruses can
affect host cell DNA, and so on. However, gene mutations can also occur
spontaneously due to occasional errors in DNA replication, even without the
influence of these external factors. Characteristics
of Gene Mutations In nature, there are many factors that can induce gene
mutations, and gene mutations can also occur spontaneously. Therefore, gene
mutations are widespread in the biological world. Because changes in DNA base
composition are random and non-directional, gene mutations exhibit randomness
and non-directionality. The randomness of gene mutations means that they can
occur at any stage of an organism's development, within different DNA molecules
inside cells, and at different locations within the same DNA molecule. The
non-directionality of gene mutations means that one gene can undergo different
mutations, resulting in more than one allele. In
natural conditions, the frequency of gene mutations is very low. It is
estimated that in higher organisms, only 1 out of 10^5 to 10^7 reproductive
cells undergoes a gene mutation. Significance
of Gene Mutations For organisms, gene mutations may disrupt the coordination
between the organism and its current environment, thus being harmful to the
organism. However, some gene mutations are beneficial to organisms, such as
mutations in plants that confer disease resistance or drought tolerance, and
mutations in microorganisms that confer drug resistance. There are also gene
mutations that are neither harmful nor beneficial; these are neutral mutations.
For example, some gene mutations do not result in new traits, and they belong
to neutral mutations. Gene
mutations are a pathway to generating new genes. For the reproduction and
evolution of organisms, organisms that have produced new genes may better adapt
to environmental changes, open up new living spaces, and thus give rise to new
types of organisms. Therefore, gene mutations are the fundamental source of
biological variation, providing rich materials for biological evolution. Gene
Recombination The law of independent assortment of genes tells us that during
the formation of gametes in organisms through meiosis, with the independent
assortment of non-homologous chromosomes, non-allelic genes also assort
independently, producing different gametes. Thus, fertilized eggs formed by the
combination of male and female gametes may have genotypes different from those
of their parents, thereby causing variation in offspring (Figure 5-4). In
addition, during the tetrad stage of meiosis, sometimes alleles on homologous
chromosomes undergo exchange with non-sister chromatids, resulting in gene
recombination on chromatids. Gene recombination refers to the recombination of
genes controlling different traits during the process of sexual reproduction in
organisms. What
is the significance of gene recombination? Generally, gene recombination during
sexual reproduction diversifies the types of gametes produced, thereby
producing offspring with diversified gene combinations. Some of these offspring
may have gene combinations necessary for adapting to certain changes essential
for survival. Therefore, gene recombination is also a source of biological
variation and is of significant importance to the evolution of organisms. |
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